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Tuesday, AN2 Therapeutics (NASDAQ:ANTX) received a rating downgrade from Leerink Partners from Outperform to Market Perform with a significant reduction in the price target to $7.00 from the previous $23.00. The downgrade follows ANTX’s announcement today concerning the diminished efficacy observed in their ongoing Phase 2 trial of epetraborole. The company is considering focusing on a subgroup of patients in the upcoming Phase 3 trial to identify those who show signs of efficacy.
The decision to narrow the enrollment criteria for Phase 3 trials is based on the lower-than-anticipated responder rate seen in the current trial phase. Leerink Partners had anticipated a solid double-digit responder rate, which has not materialized, leading to today’s update. The firm suggests that the Phase 2 results expected in the second quarter of 2024 may not be as promising as previously hoped.
Leerink Partners also noted that the potential for epetraborole’s success now hinges on identifying a specific patient subgroup that benefits from the treatment. The uncertainty surrounding which subgroup may respond has prompted the firm to adjust their model assumptions and lower their expectations for the drug candidate’s market performance.
Despite this setback, AN2 Therapeutics reported having $150.2 million in cash and investments as of September 30, 2023. This reserve is projected to cover operating expenses until summer 2025, providing the company with some financial stability as it navigates the clinical trial process.
InvestingPro Insights
In light of the recent challenges faced by AN2 Therapeutics (NASDAQ:ANTX), the InvestingPro data provides a deeper look into the company’s financial health and market performance. The adjusted market capitalization of ANTX stands at $151.68M, reflecting the market’s current valuation of the company post-announcement. Despite the negative news, ANTX retains a modest price-to-book ratio of 1.09 as of the last twelve months ending Q3 2023, suggesting that the company’s assets are still valued relatively close to their accounting worth.
However, the company’s performance metrics indicate significant headwinds, with a negative P/E ratio of -6.55, which further declined to -2.54 when adjusted for the last twelve months as of Q3 2023. This suggests that investors are concerned about the company’s profitability in the near term. Additionally, the return on assets is deeply negative at -45.24% for the same period, underlining operational challenges.
The stock’s price has experienced a steep decline, with a 1-week total return of -74.51% and a year-to-date total return of -75.11%, reflecting the market’s reaction to the recent developments and uncertainties surrounding epetraborole’s efficacy. This performance is reflected in the stock’s price, which closed at $20, a significant distance from the 52-week high, representing only 22.95% of that value.
InvestingPro Tips highlight that the next earnings date scheduled for March 27, 2024, will be a critical moment for investors to assess ANTX’s strategic plans and financial resilience. With InvestingPro’s fair value estimate at $10.55, considerably lower than analyst targets, it suggests a cautious stance on the stock’s potential recovery. For those considering a deeper analysis, the InvestingPro platform provides additional tips, with a current count of 15 more insights available to guide investment decisions. Use the coupon code PRONEWS24 to get an additional 10% off a yearly or biyearly Pro and Pro+ subscription.
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This story originally appeared on Investing
